Clotrimazole Vaginal: MedlinePlus Drug Information

Instead, wear clean, cotton socks and change them daily or more often if your feet sweat freely. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed. This combination medication is used to treat a variety of inflamed fungal skin infections such as ringworm, athlete's foot, and jock itch. I know this from doing clinical trials on tinea pedis medications and monitoring the level of inflammation during the trial. As chitosan is film forming, biocompatible, non-allergenic material it helps in protecting the skin by acting as a barrier.

The word healing as related to compromised skin conditions (cuts, wounds, infections, inflammations, abrasions, etc.) See FDA-Approved Patient Labeling (Patient Information)Inform the patient of the following: Clotrimazole cream may decrease the effectiveness of latex condoms and diaphragms during treatment and for 3 days after last use. You may need a different or additional medication to treat your infection. In the US - Call your doctor for medical advice about side effects. They cause blood vessels to widen and other inflammatory substances to arrive, resulting in the affected area of skin becoming red, swollen and itchy. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Learn more Additional Data Available Additional Data Available Blackbox Warnings Structured data representing warnings from the black box section of drug labels.

Do not use clotrimazole and betamethasone dipropionate cream on the face or underarms. These structures, although located in the dermis, protrude through the epidermis to the skin surface. However the medium chain grade chitosan delivered an optimum level of viscosity to the formulation. Some clotrimazole resistance is documented in Candida albicans, especially among oral isolates in patients with AIDS treated with Clotrimazole. They may be anionic or cationic or non-ionic in nature. In RS Gibbs et al.

Adverse events consistent with corticosteroid use have been observed in pediatric patients treated with clotrimazole and betamethasone dipropionate cream. The mean age of patients prescribed C-BMV for diaper dermatitis is 0. Accurate diagnosis is necessary for effective treatment. Dosage is based on your medical condition and response to treatment. Should I try an over-the-counter antifungal cream?

  • Ask your doctor about any risk.
  • Inform all health professionals involved in your care that you have been using corticosteroids.
  • Rub it in gently.
  • Store this medication at room temperature and keep it out of the reach of children.
  • May make these conditions worse.


It is positively charged and soluble in acidic to neutral solution. A 1% solution can be used for otitis externa. Amazon, vaginal discharge. Permanent changes to the skin will occur if potent corticosteroids are used in high concentrations over a prolonged period of time. Ringworm or jock itch is usually treated for 2 weeks, and athlete's foot is usually treated for 4 weeks. Steroid medicines can increase the glucose (sugar) levels in your blood or urine. Remember to complete the course of treatment as this will help to prevent the infection from coming back.

Stopping the medication too early may result in a return of the infection. Avoid use of clotrimazole and betamethasone dipropionate cream in the diaper area, as diapers or plastic pants may constitute occlusive dressing. Clotrimazole is active against most Candida species and skin fungi such as Trichophyton spp. The concentration of chitosan medium chain grade was carefully arrived based on several in house trials and Preclinical animal studies for efficacy. This is greatly inconvenient and also not cost effective for a majority of human population, particularly in the under-developed nations. Since the dosage form is a cream, appropriate levels of viscosity is required to achieve a good spreadability over the skin.

Most topical skin preparations are 1% cream, lotion or spray, which should be applied 2 or 3 times daily for 2-4 weeks.

Application Development Support

Avoid too much heat and humidity if possible. Do not get it into your eyes, nose, mouth, or vagina, or apply it on your face or under your arms. Avoid contact with the eyes, the mouth, or intravaginally. The cream should be applied two - four times a day depending upon the skin conditions for the full treatment period, even though symptoms may have improved. (5%) evaluable pediatric subjects (aged 12-16 years old) using clotrimazole and betamethasone dipropionate cream for treatment of tinea pedis demonstrated adrenal suppression as determined by cosyntropin testing. Taking medicine as your doctor suggests will improve your health and may prevent future problems.

Only 18% of prescribing pediatricians correctly identified C-BMV as a high potency steroid (Figure 3).

Side-effects are unlikely but may include mild skin irritation or itching. A wet mount shows parabasal cells and no lactobacilli. They are taken 5 times daily for 14 days for treatment, or 3 times daily for prevention of oral candidiasis. It was first used in patients in the late 1970’s and licensed for use in before 1982. This medicine is available only with your doctor's prescription. In a small trial, clotrimazole and betamethasone dipropionate cream was applied using large dosages, 7 g daily for 14 days (BID) to the crural area of normal adult subjects. For patients using this medicine for jock itch: Once absorbed through the skin, the pharmacokinetics of topical corticosteroids are similar to systemically administered corticosteroids.

The cream of the present invention provides an integrated uni-dose or a single-dose therapy hitherto unavailable in prescription dermaceutical formulations. Do not apply a double dose to make up for a missed one. Candida or thrush of the nipple and breast . issues and concerns. If you are having your period, ask your doctor when you should use the pessary.


Call your doctor if your symptoms do not improve during this time or if your symptoms get worse at any time during your treatment. If there is inflammation, an antifungal preparation combined with a corticosteroid may be of value. Betamethasone is a strong corticosteroid that works by reducing the swelling, redness, and itching that occurs in the skin infection. It is biocompatible with both healthy and infected skin and has been shown to be biodegradable as it is derived from shrimps, squids and crabs. MMWR , 59(RR-12): The longer the treatment time, the smaller the concentration of medicine that is used in each application. It contains two active ingredients: Check with your doctor immediately if any of the following side effects occur:

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The most common of these is Microsporum canis. Am J Dis Child 1991; 145: Let’s just say it is a pretty significant tinea infection by the time I see these patients and the patient frustration level is through the roof at that point. Is it okay to 'tough out' a yeast infection? self-diagnosing below the belt isn't always a smart decision. Chosidow O, Lebrun-Vignes B, Bourgault-Villada I.


Medications other than those listed above may interact with this medication. This medicine comes with patient instructions for safe and effective use. Wilson, Steven R.

Clotrimazole is an imidazole antifungal drug used for various mucosal and cutaneous infections. Each 1 g of white-to-off-white cream contains 10 mg of clotrimazole USP and 0. An initial treatment using oral and/or vaginal medicine is followed by 6 months to 1 year of less frequent maintenance treatment. The swallowed drug is variably but poorly absorbed. Topical clotrimazole is categorized as pregnancy category B. It is well understood that if the superficial bleeding is left untreated, it will lead to secondary microbial infections.

Clotrimazole is unlikely to cause any serious side-effects. Its etiology is closely tied to the use of occlusive footwear. A cream is a topical preparation used for application on the skin. Pediatricians still commonly prescribe the product to children under the age of 5 and for diaper rash. Thrush, your provider may prescribe an antifungal cream for your nipples. No evidence of maternal toxicity or embryotoxicity was seen in pregnant rabbits dosed orally with 60, 120, or 180 mg/kg/day (18-55 times the maximum human dose). This is because incompatibility would compromise the stability of the final product.

  • It's known properties include accelerated blood clotting.
  • After weeks of using a super-potent topical steroid consistently, one has to be concerned with the possibility of irreversible dermal atrophy, tachyphylaxis, suppression of the hypothalamic pituitary adrenal (HPA) axis, skin fragility, pigmentation changes, et cetera.
  • It has two actions which restrain the movement of water and limit the loss of water from the skin’s surface.
  • If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911.

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If you do get the medication in those areas, flush with plenty of water. Use this medication on the skin only. Medical conditions: Pediatricians were considered eligible for completion of the questionnaire if they met the following criteria: Compared with IV administration, bioavailability of an inhaled dose of Mometasone Furoate is less than 1%.

The active ingredients ketoconazole and betamethasone act, respectively, on the etiologic agent of the infection and the inflammation generated by the process, and the association of both showed a positive therapeutic response in dermatitis with confirmed secondary infections or potential yeast (analysis carried out in association with sulfate neomycin, aimed to cover bacterial infections together).

This medicine should come with a patient information leaflet. Carefully dry the feet, especially between the toes, after bathing. I suppect with this being winter time is especially helpful as well. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. The acidic scale of pH is from 1 to 7, and the base scale of pH is from 7 to 14.

Lotriderm cream is used to treat fungal skin infections when symptoms of inflammation, such as itching, require rapid relief. Tinea incognita is often incorrectly spelled as tinea incognito. Topical corticosteroid is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Pediatric patients may be more susceptible than adults to skin atrophy, including striae, when they are treated with topical corticosteroids. There are several treatments available to treat skin disorders caused by bacteria or fungi. Successful treatment of chronic vaginitis, do not use Canesten if you are pregnant, think you are or are nursing without speaking to a doctor first. Clotrimazole has been shown to be active against most strains of the following dermatophytes, both in vitro and in clinical infections, Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum [see Indications and Usage (1)].

Candidiasis Of The Skin

For more information, please see the MotherToBaby fact sheet Paternal Exposures and Pregnancy at https: Prolonged use of topical (applied to the skin) corticosteroid products may produce thinning of the skin and tissues under it. If you are pregnant or breastfeeding, apply this medicine to the smallest skin area and for the shortest amount of time possible to treat your condition. Yeast infection, it can be difficult to figure out. However, scarring and architectural changes are not reversible. You should not use Lotriderm cream on areas of skin affected by the following:

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However, in the combined fertility, teratogenicity, and postnatal development study described above, 50 mg/kg clotrimazole was associated with reduced maternal weight gain and reduced numbers of offspring reared to 4 weeks. Sometimes there are mental disorders, depression, sleep disturbance. Get emergency medical help if you have signs of an allergic reaction: The elastin gives the skin its flexibility. (1%) evaluable pediatric subjects (aged 12-16 years old) using clotrimazole and betamethasone dipropionate cream for treatment of tinea cruris demonstrated adrenal suppression as determined by cosyntropin testing. The medicine is aimed at treating hypertension. Lotrisone cream is available in Lotrisone cream 15 gram tubes and Lotrisone cream 45 gram cream tubes. If it is an inflammatory condition, give the patient a topical corticosteroid appropriate for the level of inflammation present.

This drug is a broad spectrum antimycotic or antifungal agent. Alternatively 1%, 2% or 10% vaginal cream delivering roughly the same doses as pessaries, may be used, for the same durations. Purpura (bruising) and telangiectasia (broken blood vessels ). Ketoconazole is also used occasionally for tinea infections.


This document does not contain all possible drug interactions. The following evaluates the use of this combination based upon a survey of 106 US-based pediatricians with at least two years post-residency, who attended the 1999 American Academy of Pediatrics. Do not use clotrimazole and betamethasone dipropionate cream for any disorder other than that for which it was prescribed. Steroids like Mometasone Furoate provide much wanted rapid relief of the pruritus. A slight shift towards the alkaline pH would provide a better environment for microorganisms to thrive.

It is important to use this medication exactly as prescribed by your doctor. Because tinea capitis and tinea unguium are not typically amenable to topical therapy, they will not be discussed in this article. The final product was also not aesthetically appealing without homogeneity.